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Abraham
The historical background of the iodine project.Abraham GE The Original Internist, 12(2):57-66, 2005
"Based on data available in the medical literature, urinary iodide levels are considered the best index of iodine intake. The initial results of the bioavailability study suggested that the Lugol tablets were not well absorbed since only 20 to 30% of the administered amount was recovered in the 24 hr. urine collection of 5 subjects tested. Just in case medical textbooks were wrong, and the explanation for the low recovery of iodide is body retention of iodine/iodide, the supplementation was continued for one month and then urine iodide levels were measured again in the 24 hr. urine collection. Medical textbooks were wrong and the subjects excreted a mean of 50% of the amount ingested, with one subject excreting 96% of the ingested amount."
"Because of the improved overall wellbeing reported by the subjects who achieved 90% or more iodide excreted, sufficiency was arbitrarily set as 90%. Implementation of orthoiodosupplementation based on the loading test revealed that sufficiency was not achieved in some subjects even after 2 years of iodine supplementation at 1 to 2 tablets/day. To achieve sufficiency within 3 months, most subjects required 3 to 4 tablets/day (37.5-50 mg), and some obese and diabetic subjects required even more than 50 mg/day to achieve and maintain sufficiency.
"Six normal subjects with normal body weight (3 men and 3 women) ingested 4 tablets of Iodoralā (50mg)/day for three months and were followed with monthly loading test. After three months on orthoiodosupplementation, only one female subject did not reach sufficiency. Following one month off orthoiodosupplementation, the loading test was repeated. All 6 subjects showed a significant drop of the iodide concentration in the 24 hr urine collection. In all 5 subjects who had reached sufficiency, the percent of the oral amount excreted in the 24 hr urine collection was below 90%, ranging from 64% to 82%. This drop in % excretion has been observed in some subjects after they have achieved whole body sufficiency for iodine, even though they continued to ingest 50 mg iodine/day regularly. Increased exposure to goitrogens may be the explanation. In some of these cases, the author has observed increased urine bromide excretion as high as 20 fold baseline levels following the loading test, concomitant with a drop in percent iodide excreted.
"Whole body sufficiency for iodine correlated well with overall wellbeing, and some subjects could tell when they achieved sufficiency even before knowing the results of the test. Iodine sufficiency was associated with a sense of overall wellbeing, lifting of a brain fog, feeling warmer in cold environments, increased energy, needing less sleep, achieving more in less time, experiencing regular bowel movements and improved skin complexion. In some subjects with overweight or obesity, orthoiodosupplementation resulted in weight loss, decreased percent body fat and increased muscle mass. Following orthoiodosupplementation, increased urinary excretion of the goitrogens fluoride and bromide and the toxic metals mercury, lead, cadium and aluminum was observed; marked improvement of fibrocystic disease of the breast occurred following 3 months of iodine supplementation at 50 mg/day. In 3 patients with Polycystic Ovary Syndrome with olygomeuorrhea, orthoiodosupplementation resulted in regularization of the menstrual cycle. In patients on thyroid hormones, orthoiodosupplementation resulted in a decreased requirement to much lower levels of thyroxine and in some cases, resulted in the complete discontinuation of this hormone. This decreased requirement for thyroid hormones following orthoiodosupplementation was observed in a female patient with total thyroidectomy, suggesting that iodine not only improves thyroid function but also has an effect at the target organ level. In diabetic patients on insulin, orthoiodosupplementation resulted in better control of this condition, and in some cases alleviated this condition without the need for insulin. In hypertensive patients, whole body iodine sufficiency resulted in normalization of blood pressure without medications."
"Serum inorganic iodide levels are a good index of the bioavailability of ingested iodine/iodide. Serum inorganic iodide is cleared rapidly by the kidneys with a daily clearance rate of 43.5. At steady state condition, the serum iodide levels expected for patients receiving 50 mg iodine/day should be approximately: serum iodide (mg/L) = daily intake (mg) / 43.5 Liter = 50 mg / 43.5 = 1.15 mg/L. If patients continue to excrete low levels of iodide after orthoiodosupplementation for 3 months, serum inorganic iodide levels are indicated to assess whether this is due to decreased absorption or increased demand. Malabsorption of iodine/iodide would result in very low serum inorganic iodide levels (10-8M) in the presence of low urinary excretion. We have not observed a case of malabsorption of iodine yet, when iodine supplementation was in the range of 12.5 to 50 mg/day."
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