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Wolff
A miss for NIS?Wolff J. Thyroid. 2002 Apr;12(4):295-7. Review.
"This discovery and characterization of the sodium iodide symporter (NIS) by Carrasco and colleagues (1), and the many subsequent papers based on this important finding are, for the most part, fully consistent with what has been learned in the past 50 years from physiologic iodide transport studies and clinical material. One problem that has not been resolved, however, involves the anion selectivity differences between NIS and transport studies."
"The chief problem areas stem from the high activity of ClO3- and Br- in the NIS system but not in the thyroid, and the absence of any inward current from the tetrahedral anions, ClO4-, ReO4- and, by implication, TcO4- in NIS-expressing oocytes, although they are readily accumulated in iodide-concentrating tissues. Some details regarding these discrepancies are listed below."
Congenital goiter with defective iodide transport.Wolff J. Endocr Rev. 1983 Summer;4(3):240-54. Review. [citation only]
Iodide goiter and the pharmacologic effects of excess iodide.Wolff J. Am J Med. 1969 Jul;47(1):101-24. Review. [citation only]
Iodide transport: inhibition by agents reacting at the membrane.Larsen PR, Wolff J. Science. 1967 Jan 20;155(760):335-6. [citation only]
Thyroidal iodide transport. IX. The accumulation and metabolism of selenocyanate.Wolff J, Maurey JR. Endocrinology. 1966 Oct;79(4):795-800. [citation only]
Thyroidal iodide tranpsort. 8.Alexander WD, Wolff J. Endocrinology. 1966 Mar;78(3):581-90. [citation only]
Thyroidal iodide transport. VII. Acute stimulation of thyroidal iodide concentrating ability by cystamine and cysteamine.Wolff J, Rall JE. Endocrinology. 1965 May;76:949-57. [citation only]
Thyroidal iodide transport. VI. On a possible role for iodide-binding phoshpolipids.Schneder PB, Wolff J. Biochim Biophys Acta. 1965 Jan 25;94:114-23. [citation only]
Cation requirements for iodide transport.Alexander WD, Wolff J Arch Biochem Biophys. 1964 Jul 20;106:525-6. [citation only]
Transport of iodide and other anions in the thyroid gland.Wolff J Physiol Rev. 1964 Jan;44:45-90. Review. [citation only]
Thyroidal iodide transport. V. The role of Na-K-activated, ouabain-sensitive adenosinetriphosphatase activity.Wolff J, Halmi NS J Biol Chem. 1963 Feb;238:847-51.
"1. Adenosinetriphosphatnse activity was measured in homogenates and cell fractions of thyroids and other iodide-transporting tissues of various species. An ouabain-sensitive portion of this activity has been identified and compared with various properties of the iodide transport systems of such tissues.
2. A close correspondence in the properties of the transport and enzymatic systems was found to occur in the following. (a) Sensitivity of both systems to ouabain was comparable in a variety of species over more than 1000-fold difference in ouabain concentration. (b) The potency of six different cardioactive compounds and quinidine was comparable against both systems over four orders of magnitude in concentration. Structural changes in the compounds affected both systems similarly. (c) Concentrations for half-activation by K+ are 0.9 to 1.4 mM in both systems, and partial inhibition by ouabain can be reversed by K+ in both. (d) Thyrotropic hormone given in viva stimulates the iodide-concentrating mechanism and ouabainsensitive adenosinetriphosphatase activity in parallel.
3. It is concluded that the Na+-K+-requiring, ouabainsensitive adenosine triphosphatase activity is indirectly involved in iodide transport."
Thyroidal iodide transport. IV. The role of ion size.Wolff J, Maurey JR Biochim Biophys Acta. 1963 Jan 1;69:58-67. [citation only]
Thyroidal iodide transport. III. Comparison of iodide with anions of periodic group VIIA.Wolff J, Maurey JR Biochim Biophys Acta. 1962 Mar 12;57:422-6. [citation only]
Thyroidal iodide transport. II. Comparison with non-thyroid iodide-concentrating tissues.Wolff J, Maurey JR Biochim Biophys Acta. 1961 Mar 4;47:467-74. [citation only]
Thyroidal iodine transport. I. Cardiac glycosides and the role of potassium.Wolff J Biochim Biophys Acta. 1960 Feb 26;38:316-24. [citation only]
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