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Physiology

Transporters

NIS

• Abraham

• Ajjan, Kilbane, Weetman

• Carrasco

• Colorado SU

• Costagliola

• Elisei

• Endo

• Ferreira

• Filetti

• Fujiwara

• Furlanetto

• Gene Reports

• Heufelder

• Josefsson

• Jhiang

• Kim, Chung

• Kogai

• Kotani

• Lim, Moon

• Mitchell

• Mitrofanova

• Pekary

• Perron

• Riesco-Eizaguirre

• Rhoden

• Schlumberger

• Schmitt

• Smyth

• Spitzweg

• Suzuki

• Tazebay

• Tonacchera

• Upadhyay

• Van Sande

• Venkataraman

• Yoshida, Kosugi

• Wapnir

• Wolff

SLC5A5 Gene Reports

SLC5A5

Genetics Home Reference

"The SLC5A5 gene provides instructions for making a protein called sodium-iodide symporter or NIS. In certain tissues, this protein facilitates the uptake of iodide (a negatively charged version of iodine). The NIS protein is found primarily in the thyroid gland, a butterfly-shaped tissue in the lower neck. The thyroid gland produces and releases iodide-containing thyroid hormones that play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). The NIS protein supports a remarkably efficient system that ensures iodine from the diet accumulates in the thyroid gland for the production of thyroid hormones. This system depends on the NIS protein being positioned in the cell membrane, so it can transport iodide from the bloodstream into particular thyroid cells called follicular cells.

"In addition to the thyroid gland, the NIS protein is found in breast tissue during milk production (lactation), ovaries, salivary glands, certain stomach cells (parietal cells), tear glands (lacrimal glands), and a part of the brain called the choroid plexus. During lactation, the NIS protein transports iodide into the milk to supply breast-fed infants with this critical component of thyroid hormones."

Entrez Gene. SLC5A5 solute carrier family 5 (sodium iodide symporter), member 5 [ Homo sapiens ]

NCBI

An overview of the SLC5A5 gene (NIS) in humans.  Gives technical details as well as a list of relevant research.

Gene Report: SLC5A5 (RGD: 69267)

RGD (Rat Genome Database)

Technical details of the NIS in rats, plus homologs.

Compare GO annotations for SLC5A5 and its orthologs

Graph showing relationships between SLC5A5 and orthologs.

SLC5A5. Sodium iodide symporter

Biocompare. Gene-Specific Product Directory

Description of SLC5A5 plus links.

SLC5A5; Solute carrier family 5 (sodium iodide symporter), member 5 (19p13.2-p12)

Cancer GeneticsWeb

Description and links.

SLC5A5

SOURCE Gene Reports

Description and links.

SLC5A5

Genatlas: Gene Database

Description and links.  Diagrams.

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