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Perkin
The fractionation of the iodine of the blood in thyroid disease.
Perkin HJ, Hurxthal LM.
J Clin Invest. 1939 Nov;18(6):733-7.
" A method for the fractionation of the iodine of the blood has been described: the limitations of the method have been established. Compared with the normal: (1) A decrease in the level of the organic iodine of the blood was found in patients with primary myxedema. (2) Patients with exophthalmic goiter who had not received iodine therapy were found to have an increase in the level of organic iodine in the blood. (3) A relative decrease in organic blood iodine was found in patients with exophthalmic goiter following iodine medication. (4) Patients with nontoxic goiter receiving iodine showed a relative increase in the organic iodine of the blood."
The influence of the thyroid gland and of the ovary on the metabolism of iodine
Perkin HJ, Brown BR
Endocrinology, 22:537. May 1938
"The blood iodine level of male and female dogs receiving 72 mg of iodine daily was represented graphically as a series of peaks and dips varying from 75 to 2500 (gamma) of iodine per cent of whole blood. The blood iodine level was considerably depressed following complete thyroidectomy in male dogs receiving iodine. In female dogs receiving iodine, complete thyroidectomy apparently had no influence on the blood iodine level. Following bilateral oophorectomy in the thyroidectomized female dogs, the blood iodine level decreased; the results simulated the values found in thyroidectomized male dogs.
"Iodine analyses of the tissues of dogs receiving iodine for varying periods of time indicated that, exclusive of the thyroid gland, the ovary contained approximately twice the amount of iodine per gram weight of any other tissue."
Determination of iodine in blood.
Perkin HJ.
Biochem J. 1933;27(4):1078-81.
"The purpose of this investigation was to establish a reliable and accurate method for the quantitative determination of small amounts of iodine...."
"A modified technique has been devised fror the quantitative determination of iodine, in quantities such as are present in blood. This method has an error of less than 10%. Contamination must be carefully avoided in micro-estimations of iodine. Strict adherence to an established technique is essential. The results secured, if not strictly quantitative, are at least comparable."