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Lavelle
Increased serum iodide concentration from iodine absorption through wounds treated topically with povidone-iodine.Aronoff GR, Friedman SJ, Doedens DJ, Lavelle KJ. Am J Med Sci. 1980 May-Jun;279(3):173-6. [abstract only]
"Increased serum iodide concentrations secondary to iodine absorption through wounds treated with povidone-iodine dressings is described. Hyperchloremic acidosis and a disparity between serum chloride concentrations determined by two different methods suggested the presence of an unidentified halide. Cardiovascular instability and renal failure occurred concurrent with systemic iodide accumulation. Measurement of serum iodide concentration should be performed when povidone-iodine is used topically in patients with impaired renal function."
Iodine absorption in burn patients treated topically with povidone-iodine.Lavelle KJ, Doedens DJ, Kleit SA, Forney RB. Clin Pharmacol Ther. 1975 Mar;17(3):355-62. [abstract only]
"Providone-iodine is used as a topical antimicrobial in burn patients. Although absorption of iodine has been thought to be negligible, several patients have recently been noted with substantial elevations of serum free iodide. Unexplained abnormalities occurred in several of these patients, renal failure, metabolic acidosis, and elevation of serum glutamic oxaloacetic transaminase. It is conceivable that the large iodide loads noted were at least in part responsible for these abnormalities."
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