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The Iodine Group | |
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Dela Cruz
Iodine absorption after topical administration.Dela Cruz F, Brown DH, Leikin JB, Franklin C, Hryhorczuk DO. West J Med. 1987 Jan;146(1):43-5.
"Absorption from povidone-iodine preparations after topical administration has been reported to be negligible, but an elderly woman had increased serum iodine levels with possible metabolic complications after povidone-iodine solution was applied to decubitus ulcers."
"We also present a review of topical iodine absorption and systemic complications associated with topical administration."
"The reports of iodine absorption from topical povidone-iodine solution suggest that absorption is enhanced when the compound is applied to denuded skin, mucosal surfaces with high absorptive capacity or extensive areas of intact skin. The evidence for iodine absorption includes documented serum iodine concentrations and thyroid function abnormalities."
"Most cases in which increased serum iodine concentrations are reported have involved burn patients. In addition, serum iodine concentrations have become elevated following application of povidone-iodine dressings to extensive surgical wounds, after vaginal instillation, and after application to the umbilical cord and an inch of surrounding skin of neonates. Perinatal exposure to povidone-iodine infusion resulted in elevated iodide levels in both mothers and neonates."
"Urinary iodine excretion in patients with renal failure has been shown to be minimal -- that is 150 mcg per day -- compared with that in patients with normal renal function -- 912,000 mcg per day. Immature kidney function may explain iodine accumulation in neonates."
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