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Arena
[Iodine overload in newborn infants caused by the use of PVP-iodine for perineal preparation of the mother in vaginal delivery]Arena Ansotegui J, Emparanza Knorr JI, San Millan Vege MJ, Garrido Chercoles A, Eguileor Gurtubai I. An Esp Pediatr. 1989 Jan;30(1):23-6. Review. Spanish. [abstract only]
"The high incidence of
transient thyroid dysfunction in newborns from our hospital
(0.6%), led us to investigate whether povidone perineal prep.
during delivery and daily postpartum antisepsis, induced iodine
overload in the newborn, and whether breast milk was the vehiccle.
In a controlled randomized trial we used either povidone-iodine
or clorhexidine in 36 mothers, and we investigated in them and in
their newborns iodine levels and thyroid function. Iodine levels
in cord blood, maternal urine and newborn urine were
significantly higher in povidone treated group (p less than
0.001) up to the 4th postpartum day. These levels were also
significantly higher in breast fed than in formula-fed babies
within the group of povidone-iodine-treated mothers. Maternal
prepartum urine iodine, and thyroid function in mothers and
newborns were not significantly different in both groups." |
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