|
|
The Iodine Group | |
|
Home | Orthoiodosupplementation | Body | Disease | Special | Overviews |
||
|
|
XU, Hou
Selenium supplement alleviated the toxic effects of excessive iodine in mice.Xu J, Yang XF, Guo HL, Hou XH, Liu LG, Sun XF. Biol Trace Elem Res. 2006 Summer;111(1-3):229-38. [abstract only]
"The relationship between the iodine intake level of a population and the occurrence of thyroid diseases is U-shaped. When excessive iodine is ingested, hypothyroidism or hyperthyroidism associated with goiter might develop. The aim of the study was to evaluate the effect of Se supplementation on the depression of type 1 deiodinase (D1) and glutathione peroxidase (GSHPx) activities caused by excessive iodine. D1 activity was assayed by the method with 125I-rT3 as a substrate. Compared to the effect of iodine alone, iodine in combination with selenium increased the activities of D1 and GSHPx. The addition of selenium alleviated the toxic effects of iodine excess on the activities of D1 and GSHPx."
Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake.Yang XF, Hou XH, Xu J, Guo HL, Yinq CJ, Chen XY, Sun XF. Biomed Environ Sci. 2006 Aug;19(4):302-8. [abstract only]
"OBJECTIVE: To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. METHODS: Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined. RESULTS: Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and Dl as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression. CONCLUSION: Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention."
[Effect of selenium supplement on the disordered lipid metabolism induced by the overdose of iodine in mice]Xu J, Yang XF, Guo HL, Hou XH, Chen X, Sun X. Wei Sheng Yan Jiu. 2006 Jan;35(1):52-4. Chinese [abstract only]
"OBJECTIVE: To explore the
effect of selenium supplement on the disordered lipid metabolism
induced by the overdose of iodine in mice. METHODS: The 80 Balb/c mice
were randomly divided into eight groups, the normal control group, the
high iodine group (drunk the water containing iodine 3000 microg/L)
and six selenium groups (drunk the water containing iodine 3000 microg/L
and selenium 0.1, 0.2, 0.3, 0.4, 0.5, 0.75 mg/L). The total
cholesterol and triglyceride in serum and liver were determined.
RESULTS: The total cholesterol in serum, the total cholesterol and
triglyceride in liver of high-iodine group increased significantly
compared with normal control group. There is no difference between
normal control group and the group drunk the water contained 0.2 mg/L
selenium. CONCLUSION: It suggests that it is an effective intervention
dosage to drunk water containing 0.2 mg/L selenium."
[Influences of excess iodine on thyroid hormone concentrations in cerebrum of filial mice and intervention of selenium]Guo HL, Hou XH, Yang XF, Xu J. Wei Sheng Yan Jiu. 2006 Mar;35(2):194-5. Chinese. [abstract only]
"OBJECTIVE: To study the
influence of excessive iodine intake on thyroid hormones in cerebrum
of filial mice and intervention of selenium. METHODS: 60 Balb/c mice
were divided randomly into 4 groups: control group, iodine group,
selenium group and iodine plus selenium group and given tape water,
tape water containing iodine 3000 microg/L, tape water containing
selenium 200 microg/L and tape water containing iodine plus selenium
200 microg/L respectively as drinking water. At the end of the fourth
month, the mice mated. Thyroid hormones and TSH in serum and in
cerebrum of filial mice were determined at the postnatal 0, 14th and
28th day. RESULTS: At the postnatal 14th day, serum TT4 level was
lower significantly, and serum TSH was higher in iodine group than
those in control group and in the iodine plus selenium group. At the
postnatal 0 day and 14th day, thyroid hormone concentrations in the
cerebrum of progeny of mice were lower significantly in iodine group
than those in control group, selenium group and iodine plus selenium
(P < 0.05). No significant difference was observed among the four
groups in TT4, TT3 and rT3 concentrations in serum and cerebrum at the
postnatal 28th day. CONCLUSION: Excessive iodine intake can change
thyroid hormone concentrations in the cerebrum of progeny of mice and
selenium supplementation exerted favorable effects on it."
[Effect of high-iodine intake on MBP mRNA expression in cerebrum of filial mice and selenium intervention]Hou XH, Yang XF, Sun XF, Guo HL, Xu J, Chen X. Wei Sheng Yan Jiu. 2005 Jul;34(4):428-30. Chinese. [abstract only]
"OBJECTIVE: To study the effect of selenium supplementation on myelin basic protein (MBP) mRNA expression in cerebrum of high-iodine intake filial mice. METHODS: 135 weanling female Balb/C mice were assigned into 3 groups and given drinking water including different doses of iodine and selenium. Normal control (NC, tap water), high iodine intake group (HI, 3.0 mg/L I of drinking water), high iodine intake and selenium supplementation group I (HI + Se, 3.0 mg/L I + 0.5 mg/L Se of drinking water). All the male and female mice were mated after 4 months later, related indicators of filial mice on 14 day were determined. RESULTS: In filial mice, compared with NC group, serum TT4 decreased significantly in HI groups, TT3 also decreased, and mRNA expression of MBP in cerebrum was down-regulated 27%. The selenium suppleme ntation groups inhibited the decrease of TT4 and TT3, up regulated the m RNA expression of MBP in cerebrum. CONCLUSION: High-iodine Intake can decrease thyroxine of filial mice, which maybe is the reason for down-regulated m RNA expression of MBP in cerebrum, and selenium can exert some intervention by thyroxine, but need to verify more."
[Effect of selenium on liver type I deiodinase in iodine-excess mice]Hou X, Yang X, Pang H, Zhang X, Qi Z, Yu D, Sun X. Wei Sheng Yan Jiu. 2004 Nov;33(6):678-80. Chinese. [abstract only]
"OBJECTIVE: To investigate the effect of selenium on the activities of liver type I deiodinase (IDI) in iodine-excess mice. METHODS: Forty female weanling Balb/c mice of 18-22 body weight were randomly divided into 5 groups: normal control group (N, deionized water), iodine-excess group I (IE I, 3 mg/L Iodine water), IE I + Se group (+ 1 mg/L Se water), iodine-excess group II (IE II, 5 mg/L Iodine water) and IE II + Se group (+ 1 mg/L Se water), and they were fed with standard diets and different level of iodine and selenium water for 12 weeks. RESULTS: Iodine-excess groups show diffused colloid goiter; Serum TT4 of two iodine-excess groups were significantly higher than Normal control, and TT3 of IE II decreased significantly; The selenium level and IDI activity of mice liver was decreased significantly in iodine-excess group, but no difference between IE I and IE II. CONCLUSION: Iodine-excess intake can decrease the selenium level and IDI activity of mice liver, which maybe is the reason to increase the serum TT4 level and lead to goiter, and selenium can alleviate that."
|
|
Home | Orthoiodosupplementation | Body | Disease | Special Topics | OverviewsThe Iodine Group | Books | Disclaimers | Contact Us | Search
|
||
