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Kvicala
Effect of iodine and selenium upon thyroid function.Kvicala J, Zamrazil V. Cent Eur J Public Health. 2003 Jun;11(2):107-13. [abstract only]
"Iodine is an
essential element with unique role in organism: it is
indispensable component of thyroid hormones. After binding with
specific nuclear receptor, T3/T4 induce transcription of genetic
code via mRNA and regulate proteosynthesis in most tissues.
Thyroid hormones regulate rate of metabolic processes and
consequently development of organism. Czech Republic was in past
typical region with moderate to severe iodine deficiency.
Therefore epidemiological survey was started in randomly selected
samples of peoples. Thereafter a complex program of improving
iodine supply was realized. Prompt effects of this changes were
recorded, namely increase of ioduria and decrease of thyroid
volume. Essential trace element selenium has a fundamental
importance to the cell and body metabolism regulation by thyroid
hormones. Activities of selenoenzymes deiodinases lead to the
activation of prohormone T4 to active hormone T3 and the
inactivation of T3 and of T4, as well. There is unfortunately
moderate to mild Se deficit in the CR. Average serum Se
concentrations for the populations from 6 to 65 years are in the
regions of the CR between 42 and 62 micrograms/l and urine Se
values are between 8 and 15 micrograms/l. We have found
statistically significant correlations among indexes of selenium
status and indexes of thyroid hormone metabolism and function.
Especially dangerous are concomitant deficiencies of both key
elements for thyroid hormone metabolism--I and Se--from the point
of thyroid hormone regulative functions." |
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