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Soldin
Do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations?Soldin OP, Tractenberg RE, Pezzullo JC. Ther Drug Monit. 2005 Apr;27(2):178-85. [abstract only]
"The toxicity of
environmental chemicals such as nitrates, thiocynates, and
perchlorates, some therapeutics, and dietary goitrogens can lower
thyroidal iodine uptake and result in hypothyroidism and goiter.
Iodine sufficiency, essential for normal thyroid hormone
synthesis, is critical during gestation to assure that sufficient
thyroxine (T4) and iodine reach the developing fetus. Spot
urinary iodide (UI) measurements are used globally to indicate
and monitor iodine sufficiency of populations. In individuals,
however, UI are not routinely measured; instead, normal serum
thyroid-stimulating hormone (TSH) and T4 concentrations serve as
surrogate indicators of iodine sufficiency as well as thyroidal
health. Our objective was to examine the relationship between UI
concentrations and serum T4 and TSH concentrations in individuals
in an "iodine-sufficient population." Using a cross-sectional
sample of the US population (n = 7628) from the National Health
and Nutrition Examination Survey (NHANES III; 1988-1994)
database, we examined the relationship among UI, T4, and TSH in
pregnant and nonpregnant women and in men (15-44 years). There
was a lack of relationship between UI (or UI/Cr) concentrations
and serum T4 or TSH concentrations. Therefore, TSH and T4 are not
appropriate markers of UI concentrations in this population.
Monitoring the status of iodine nutrition of individuals in the
United States may be important because serum TSH and T4
concentrations do not indicate low iodine status."
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