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Imamura, Fujii
Quantitative in vivo measurement of thyroidal iodine content by static x-ray fluorescent technique: some preliminary clinical observations.Imamura K, Sasaki Y, Sekita N, Someya K, Fujii M. Invest Radiol. 1979 Jul-Aug;14(4):316-22. [abstract only]
"A static x-ray fluorescent technique utilizing an 241Am source of low activity and a wide view diverging collimator which allows in vivo determination of the concentration and total content of iodine in the thyroid is described. Determinations of normal thyroidal iodine concentration and total iodine content were as follows: 0.40 mg/g and 10.6 mg for 16 men, and 0.67 mg/g and 17.6 mg for 14 women. This fluorescent system has been applied to 70 patients to date. Thyroidal iodine concentrations in patients with Graves' disease were approximately equal to those in healthy suspects, and little change was observed among the concentrations in patients before, during, or after treatment. In most of the patients with chronic or subacute thyroiditis, concentrations levels were lower."
[In vivo X-ray fluorescent analysis of iodine concentration in the thyroid (author's transl)]Imamura K, Sasaki Y, Uji T, Someya K, Fujii M. Radioisotopes. 1977 Dec;26(12):858-63. Japanese. [abstract only]
"A simple apparatus was made for the X-ray fluorescent analysis of iodine concentration of the thyroid. The apparatus consists of 241Am gamma-ray source of 300mCi and pure Ge detector of 50mm2X5mm. Diverging collimator was designed to achieve a full view of the thyroid. The detectable concentration was 0.2mg iodine/g tissue assuming the coefficient of variance of 30% and the counting time of 5 minutes. Measurement was performed for autopsied 10 thyroids and the results were in good correlation with those by neutron activation analysis (r=0.93). Iodine concentration ranged 0.3-1.2mg/g (mean 0.6mg/g) and compared well with the data in literatures. This technique is useful for the in vivo measurement of thyroidal iodine content in patients."
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