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INCHEM
Bromide Ion
"After oral ingestion bromide is rapidly and completely absorbed in the gastrointestinal tract and distributed almost exclusively in the extracellular fluid. The similarity of bromide to chloride gives rise to an important pharmacokinetic interaction. The two ions compete for reabsorption in the kidney. High chloride reabsorption will lead to higher bromide excretion and vice versa. The biological half-life of bromide can be decreased by administration of chloride. A normal half-life of bromide in the rat of 3 days will increase to 25 days on a chloride-free diet.
"Bromide exerts various toxicological effects in rats. At high doses effects on the central nervous system were observed. In short-term toxicity studies motor incoordination of the hind legs and inhibition of grooming were found. The main effects of bromide are on endocrine organs. It is assumed that bromide acts directly on organs such as the thyroid, adrenals and testes, thereby inducing alteration in the pituitary gland by feed-back mechanisms. The effect on the thyroid may be explained by interaction with iodide uptake and is the most sensitive effect in animal experiments."
"LEVEL CAUSING NO TOXICOLOGICAL
EFFECT |
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