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Fa-Fu
The Relationship of a Low-Iodine and High-Fluoride Environment to Subclinical Cretinism in XinjiangLin Fa-Fu, Aihaiti, Zhao Hong-Xin, Lin Jin, Jiang Ji-Yong, Maimaiti, and Aiken. Iodine Deficiency Disorder Newsletter 1991 August Vol. 7 No. 3
"We studied a total of 769 schoolchildren of
7-14 years in three areas, characterized by intakes of (A) low
iodine, high fluoride; (B) low iodine, normal fluoride; and (C)
iodine supplemented, normal fluoride. Results for the following
parameters for areas A, B, and C, respectively were: (a) average
IQ: 71, 77, 96; (b) average auditory threshold (in dB): 24, 20,
16; (c) bone age retardation (%): 28, 13, 4; (d) thyroid 131I
uptake (%): 60, 50, 24; and (e) serum TSH (mU/ml): 21, 11, 6.
Statistically significant differences existed between these
areas, suggesting that a low iodine intake coupled with high
fluoride intake exacerbates the central nervous lesions and the
somatic developmental disturbance of iodine deficiency. The
detection rate of subclinical endemic cretinism in children with
mental retardation was 69%, and the total attack rate of
subclinical endemic cretinism 9%." |
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