BEST. Halogens: fluorine, chlorine, bromine -- Research

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Special Topics Halogens Abraham Baker BEST Blount Braverman Brownstein Buchberger Crohn De Groef Derry Durrant-Peatfield Fa-Fu Fields Galletti Ginsberg Hershman INCHEM iThyroid Jooste Kirk Krueger Langer Miller Mitchell Pavelka, Babicky, Vobecky Rauws Scinicariello Shevin Simchowitz Susheela Takahashi Tonacchera Utiger Van Leeuwen, Loeber, Sangster Wolff Xiang Zhang Zhao	BEST (Board on Environmental Studies and Toxicology) Health Implications of Perchlorate Ingestion (2005) Board on Environmental Studies and Toxicology "Because of the controversy surrounding the concentration at which perchlorate should be regulated, EPA, the Department of Defense (DOD), the Department of Energy (DOE), and the National Aeronautics and Space Administration (NASA) asked the National Research Council (NRC) to assess the adverse health effects of perchlorate ingestion from clinical, toxicologic, medical, and public-health perspectives. They also asked the NRC to evaluate the scientific literature, including human and animal data, and to assess the key studies underlying EPA’s 2002 draft risk assessment, Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization, with respect to quality, reliability, and relevance for drawing conclusions about the health implications of exposure to low concentrations of perchlorate in drinking water. In response to the request, NRC convened the Committee to Assess the Health Implications of Perchlorate Ingestion, which prepared this report. Fluoride in Drinking Water: A Scientific Review of EPA's Standards (2006). Effects on the Endocrine System. Board on Environmental Studies and Toxicology "The Agency for Toxic Substances and Disease Registry (ATSDR 2003) discussed four papers on thyroid effects and two papers on parathyroid effects and concluded that "there are some data to suggest that fluoride does adversely affect some endocrine glands." McDonagh et al (2000a) reviewed a number of human studies of fluoride effects, including three that dealt with goiter and one that dealt with age at menarche. The following section reviews material on the effects of fluoride on the endocrine system--in particular, the thyroid (both follicular cells and parafollicular cells), parathyroid, and pineal glands."
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