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Stone
The role of the primitive sea in the natural selection of iodides as a regulating factor in inflammation.Stone OJ. Med Hypotheses. 1988 Mar;25(3):125-9.
"Iodides have many non-endocrine biologic effects, including a role they play in the physiology of the inflammatory response. Iodides when given systemically or applied locally increase the movement of granulocytes into areas of inflammation. They improve the phagocytosis of bacteria by granulocytes and the ability of granulocytes to kill bacteria. They alter native protein to make it more susceptible to enzymes produced by granulocytes. They increase glandular secretions and make mast cells more labile.
"They concentrate around tumors and granulomas in man and animals. They also move into areas of tissue injury. When iodide is redistributing around sites of tumors or injuries there is decreased thyroid uptake and decreased renal excretion. The multiple effects of iodides have suggested that iodide may have a physiological role in inflammation. Iodides were once used widely in medicine, especially before a cure for syphilis. Understanding the many known effects of iodides requires crossing multiple fields.
"The purpose of this paper is to propose that the rising iodide content of the primitive sea played a role in the natural selection of a system which helped the organism recover from tissue injury or invasion. As primitive life forms underwent mutations those with a defense system more responsive to environmental factors, such as iodide, had the best chance of survival. It was important for a defense system to move to any point of surface injury. The diverse biologic effects of iodides suggest a very primitive role. This effect was so important that it was later internalized so that today iodides are concentrated in the host around sites of injury or tumor growth.
"For the purposes of this paper, the effects of iodides on inflammation and the redistribution of iodides around sites of injury or tumor growth will be emphasized. Iodides' endocrine role is of undoubted great significance; so mush so, that it has overshadowed other functions."
What are the non-endocrine biologic effects of iodides?Stone OJ Med Times. 1971 Dec;99(12):143-9 passim. [citation only]
How iodides cure sporotrichosis by increased inflammation.Stone OJ. Tex Med. 1969 Apr;65(4):53-4. [citation only]
Iodide enhancement of inflammation--experimental with clinical correlation.Stone OJ, Willis CJ. [citation only]
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