Home | Orthoiodosupplementation | Body | Disease | Special | Overviews

Orthoiodosupplementation

How Much Iodine?

• Abraham

• Fuse

• Haddow

• Joanta

• Konno

• Lupachik

• Perkin

• Roti

• Seal

• Teng

• Utiger

• Yang, Li

• Yang, Sun

• Yin

• Wolff

• Zhao

• Zhou

Hyperthyroidism

Yang, Sun

Developmental toxic effects of chronic exposure to high doses of iodine in the mouse.

Yang XF, Xu J, Hou XH, Guo HL, Hao LP, Yao P, Liu LG, Sun XF.

Reprod Toxicol. 2006 Nov;22(4):725-30. Epub 2006 Jun 13.

"Chronic exposure to high doses of iodine induces thyroid dysfunction, but effects of chronic exposure to high amounts of iodine on pregnancy and fetal outcome are uncertain. In the present study, Balb/C mice were given different doses of iodine at the levels of 0 (sterile water), 1,500, 3,000, 6,000, 12,000 and 24,000 micro g/L in drinking water for 4 months, then were mated and the developmental toxicity and teratogenicity were evaluated. An obvious colloid goiter was observed, and serum total thyroxine (TT4) levels increased and serum total triiodothyronine (TT3) levels decreased significantly in dams when iodine dose reached 3,000 micro g/L. Maternal effect was evident by the reduction of average daily food consumption in higher doses of iodine groups. Embryotoxicity and teratogenicity were mainly indicated by the reduced body weight in female fetuses, the decreased number of live fetuses, and the increased incidence of resorptions, and especially skeletal variations. These results suggest that exposure to maternally toxic doses of iodine may have a potential developmental toxic effect."

 Home | Orthoiodosupplementation | Body | Disease | Special Topics | Overviews  

The Iodine Group | Books | Disclaimers | Contact Us | Search  

  Copyright: Zoe, 2006.