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Mastorakos
Thyroid CancerMastorakos G, Nezi M, Papadopoulos C The Iodine Deficiency Disorders, Chapter 20, p 37.
"Iodine supplementation is accompanied by a change in the epidemiological pattern of thyroid cancer with an increased prevalence of occult papillary cancer discovered at autopsy (201, 202). Therefore, the prognosis of thyroid cancer is significantly improved following iodine supplementation due to a shift towards differentiated forms of thyroid cancer that are diagnosed at earlier stages.
"Moreover, careful monitoring of the incidence of thyroid cancer in Switzerland following iodine supplementation showed that the incidence of thyroid cancers steadily decreased from 2 to 3 per 100 000 in 1950 to 1 to 2 per 100 000 in 1988, i.e. during a period when iodine intake increased and reached an optimal value (203).
"Finally, fine-needle aspiration biopsies were performed in Poland between 1985 and 1999 in 3,572 patients treated by thyroidectomy and were compared to the results of postoperative histopathological examinations. The particular interest of that study is that Poland used to be an endemic goiter area and that iodine deficiency was progressively corrected during the study period 1985-1999. The frequency of neoplastic lesions significantly decreased throughout the examined period and the ratio of the papillary/follicular carcinomas increased....
"Overall, it appears that correction of iodine deficiency decreases the risk of, and the morbidity from, thyroid cancer."
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