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Kristensen
Development of hyperthyroidism in nodular goiter and thyroid malignancies in an area of relatively low iodine intake.Kristensen HL, Vadstrup S, Knudsen N, Siersbaek-Nielsen K. J Endocrinol Invest. 1995 Jan;18(1):41-3. [abstract only]
"A high incidence of
toxic nodular goiter has recently been described in areas of
relatively low iodine intake. We studied the development of
hyperthyroidism in nodular goiter and thyroid malignancies in an
area of relatively low iodine intake (median 87 micrograms/h).
The material comprised a total of 557 patients admitted to our
department in the period 1978-88. The follow-up material
consisted of 214 patients with a median age of 55 yr (19-86).
Eighty-eight percent were females. The period of observation was
33 months (1-205). All patients had technetium thyroid scans,
serum T3, serum T4, T3 uptake test and serum TSH performed. TRH
tests were performed in 58 patients. During the follow-up period
45 initially euthyroid patients became hyperthyroid (18%). The
incidence increased with age, and the median age in the group,
who developed hyperthyroidism, was 65 yr. An estimated minimal
incidence of toxic nodular goiter was 23/100,000/yr. Contrary to
previous assumption, hyperthyroidism developed frequently in
elderly patients with nodular goiter in a low iodine intake area.
Thyroid cancer was found in 13 patients corresponding an
estimated incidence of 1.5/100,000/yr. The cancer incidence was
very low compared to other nordic countries with high iodine
intake. This finding may suggest a possible influence of iodine
intake on the incidence of thyroid cancer." |
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