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Thyroid Physiology

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Thyroid Cancer

• Abraham

• Carrasco

• Chow

• Feldt-Rasmussen

• Filetti, Arturi

• Franceschi

• Gartner

• Jeong, Kim

• Kogai

• Kristensen

• Maier, Krohn, Paschke

• Mastorakos

• Mutaku, Many

• Neumann, Paschke

• Park

• Ringel

• Schlumberger

• Skubis-Zegadlo

• Smit

• Son

• Spitzweg

• Venkataraman

• Verkooijen

• West

• Xing, Sidransky

• Zaichick

ABRAHAM

The concept of orthoiodosupplementation and its clinical implications.

Abraham GE

The Original Internist, 11(2):29-38, 2004

"Elevated TSH induces hypertrophy, whereas intrathyroidal iodine deficiency induced thyroid hyperplasia. In iodine-deficient goiter, iodine supplementation abolishes not only hypertrophy, but also hyperplasia of the thyroid gland. On the other hand, suppression of TSH with T4 abolishes hypertrophy, not hyperplasia if there is intrathyroidal iodine deficiency. Therefore, administration of T4 to iodine-deficient patients does not decrease their risk for thyroid cancer, an effect expected with iodine supplementation."

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