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Thyroid Disease

Hypothyroidism

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Prager, Gardner

Iatrogenic hypothyroidism from topical iodine-containing medications.

Prager EM, Gardner RE.

West J Med. 1979 Jun;130(6):553-5.

" Hypothyroidism developed in a 31-year-old woman following 22 months of treatment of an unhealed perineal fistula with iodoform-impregnated packing strips and povidone-iodine solution. Use of these topical iodine-containing medications was discontinued and the patient placed on a regimen of thyroxine. Nine months later the thyroxine administration was stopped, and the patient promptly regained normal thyroid function. Induction of reversible hypothyroidism under these circumstances could be attributed to prolonged administration of excess iodine, which in rare persons leads to goiter or hypothyroidism, or both. The novel feature of this report is that iodine in topical rather than ingested or injected form was found to be the cause of the thyroid dysfunction."

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