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Thyroid Physiology  

Thyroid Disease

Hyperthyroidism

• Abraham

• Azizi

• Galletti

• Noh, Ito

• Pedersen, Laurberg

• Ross

• Roti, Braverman

• Wartofsky

• Wolff

• Yang, Li

Abraham

The historical background of the iodine project.

Abraham GE

The Original Internist, 12(2):57-66, 2005

"For hyperthyroidism, physicians then used Lugol solution in daily amounts ranging from 6 mg to 180 mg, with the most common dose of 90 mg, resulting in success rates as high as 90%. Radioiodide and goitrogens called antithyroid drugs were not available to U.S. physicians until the late 1940’s, after World War II.

With the advent of radioiodide and goitrogens as alternatives to Lugol solution in patients with hyperthyroidism, thyroidologists became very destructive, causing hypothyroidism in 90% of these unfortunate patients."

"In a survey of U.S. thyroidologists, some 70% used radioiodide to treat hyperthyroidism instead of Lugol solution used previously to treat this condition safely and effectively with a success rate as high as 90%, compared to a thyroid destruction rate of 90% with radioiodide."

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