Home | Orthoiodosupplementation | Body | Disease | Special | Overviews

Thyroid Physiology  

Thyroid Disease

Goiter

• Abraham

• Brix

• Dugrillon, Gartner, Pisarev

• Flechas

• Furlanetto

• Hennemen

• Hintze

• Jooste

• Kahaly

• Koutras, Papanastasiou

• Kreissl

• Lee

• McClendon

• Meng

• Rasmussen

• Shomon

• Stubner

• Studer, Derwahl

• Wolff

HENNEMEN

Chapter 17.  Multinodular Goiter

Hennemen G

"The incidence of goiter, diffuse and nodular, is very much dependent on the status of iodine intake of the population. In areas of iodine deficiency, goiter prevalence may be very high and especially in goiters of longstanding multinodularity, develops frequently…. In general, in iodine sufficient countries the prevalence of multinodular goiter is not higher than 4%…. There is no correlation between the size or any other morphological hallmark of a single follicle and its iodine uptake....

"Evidence accumulated from many studies indicates that iodine deficiency or impairment of iodine metabolism by the thyroid gland, perhaps due to congenital biochemical defects, may be an important mechanism leading to increases in TSH secretion. Since in experimental animals the level of iodine per se may modulate the response of thyroid cells to TSH, this is an additional mechanism by which relatively small increases in serum TSH level may cause substantial effects on thyroid growth in iodine-deficient areas. Koutras et al. found that the thyroidal iodine clearance of patients with nontoxic nodular goiter in Scotland was, on average, higher than that in normal persons. This finding was interpreted as a reflection of a suboptimal iodine intake by such patients."

 Home | Orthoiodosupplementation | Body | Disease | Special Topics | Overviews  

The Iodine Group | Books | Disclaimers | Contact Us | Search  

  Copyright: Zoe, 2006.