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SZYBINSKI
Is iodine prophylaxis (IP) a protective factor against gastric cancer in iodine deficient areas?Szybinski Z, Rachtan J, Huszno B, Hubalewska A, Buziak-Bereza M, Trofimiuk M 30th Annual Meeting Of European Thyroid Association Istanbul, Turkey, 18-22 September 2004
“Epidemiological data reveal an association between gastric cancer incidence rate (GCIR) and iodine deficiency (ID) in endemic goiter areas. The “Venturi hypothesis” is based on the correlation between ID and high GC mortality rate due to common derivation of thyroid gland and stomach from primitive gut. Gastric mucosa and thyroid folliculi can accumulate iodine, have similar enzymes involved in iodine metabolism, are able to iodise tyrosine and express similar cross-reacting antigens…. CONCLUSIONS: Significant positive correlation between iodine nutrition on the population level and decrease of GCIR seems to support “Venturi hypothesis” in Poland. Presented data indicate the protective role of IP against gastric cancer.”
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