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Thyroid Physiology

Thyroid Regulation  

• Abraham

• Boeynaems, Braekman, Dumont

• Brix

• Carrasco, Eng

• Dugrillon, Gartner, Pisarev

• Fozzatti

• Rapoport

• Wolff

WOLFF

Iodide goiter and the pharmacologic effects of excess iodide.

Wolff J.

Am J Med. 1969 Jul;47(1):101-24. Review.

A classic article on the Wolff-Chaikoff effect. "With increasing single doses of iodide, thyroidal organic iodine formation increases to a maximum following which there is a sharp decrease in the formation of organic iodine....It is highly probable that failure to escape from inhibition accounts for or contributes to iodide goiter in man. A number of mechanistic proposals for the iodide effect have been made but have not been proved.... A second major effect of excess iodide is to inhibit release of organic iodine from the thyroid."

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