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Thyroid Physiology  

Thyroid Hormones

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Leonard

Intracellular Pathways of Iodothyronine Metabolism

Leonard L, Koehrle J

in Braverman LE, Utiger RD, The Thyroid, 8th ed. 2000, pp 136-173.

"In 1915, Kendall isolated the principal secretory product of the thyroid gland, thyroxine (T4).  Four decades later, triiodothyronine (T3), an iodothyronine three to four times more potent than T4 in eliciting metabolic responses, was identified in thyroidal extracts.  Although initially it was thought that T3 was exclusively of thyroidal origin, in 1955 Pitt-Rivers and coworkers proposed that in vivo conversion of T4 to T3 occurred in athyrotic humans; however this proposal was later retracted.  Two years later, the presence of T3 in serum of athyrotic patients was reported, but the conversion of T4 to T3 was not accepted until 1970, when the generation of T3 from therapeutic doses of T4 in athyrotic patients and the conversion of T4 to T3 in normal humans were demonstrated."

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