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Iodine and the Body

Iodine and Skin

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Iodine Absorption

Brown-Grant

The distribution of radio-iodide in the skin of the rat.

Brown-Grant K, Pethes G, Rogers AW

J Physiol. 1960 Jul;152:467-73

1. The existence of a skin:blood concentration ratio for 131-I greater than 1.0: 1 in the first few hours after injection in suckling and adult rats has been confirmed.

2. Measurements of the l31-I content of macroscopic horizontal sections of frozen skin have shown that the highest concentration occurs in the outer epidermal layer and that 131-I is preferentially discharged from this region by thiocyanate.

3. Autoradiographic studies have shown that the 131-I that can be discharged by thiocyanate is located in the lower layers of the epidermis. A concentration of 131-I in the region of the hair follicles has also been observed.

4. Some possible explanations for the existence of an iodide concentrating mechanism in the epidermis of the rat are discussed briefly."

Concentration of radio-iodide in the skin of the rat.

Brown-Grant K, Pethes G

J Physiol. 1959 Oct;148:683-93.

" 1. After injection of radio-iodide into suckling and adult rats a high percentage of the dose can be recovered from the skin in the first few hours.

2. The radioactivity of the skin at this time is due to the presence of radioiodide in equilibrium with the blood; the uptake can be reduced or iodide already present can be discharged by administering KSCN.

3. The high skin: blood ratios (2-0-5.0) observed, and the results of thiocyanate administration, suggest that an active concentrating mechanism is involved.

4. No concentration was observed in the skin of the mouse or the guinea pig and thiocyanate had no effect on skin content of 131-I in these species.

5. The initially high skin content of 131-I falls rapidly in the adult and slowly in the suckling until about 3% of the injected dose is present in the skin at 24 hr in the adult and at 260 hr in the suckling. This residual radio-iodide is present in the hair.

6. Some implications of these findings are discussed."

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