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ESCOBAR
Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man.Pedraza PE, Obregon MJ, Escobar-Morreale HF, del Rey FE, de Escobar GM. Endocrinology. 2006 May;147(5):2098-108. Epub 2006 Feb 2.
"As already described for the liver, lung, brain, and BAT, the patterns of change in T3 varied greatly among these other tissues. The greatest difference was found between the patterns for the ovary and adrenal. In the ovary there is a very remarkable increase of T3 in the animals on LID [Low Iodine Diet] + 1.0 [1.0 mcg I/20g], LID + 0.5, and LID, compared with LID + 5.0, with an almost 2-fold increase in the LID + 0.5 group. Ovarian T3 is still higher than that of the controls, even in the LID' [Low Iodine Diet + perchlorate] group, in which serum T3 was decreased by about 50%."
"The most unexpected and striking results are those obtained for the concentration of T3 in the ovary and lung, where it is much higher, and in the adrenal, where it is much lower, than expected from the normal circulating T3."
"The findings in the ovary may underlie the observation that even very severely I-deficient animals are easily mated, do not show decreased fertility, and bear litters of normal size, in contrast to Tx or goitrogen-treated hypothyroid females."
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