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Rowlands
Studies on the concentration of radioiodide and thiocyanate by slices of the salivary gland.Fletcher K, Honour AJ, Rowlands EN Biochem J. 1956 Jun;63(2):194-9.
1. It has been found that slices of
salivary glands of the mouse concentrate [131-I] iodide 5-10 times
from the surrounding medium.
2. All the 131-I in the gland is
present as iodide; no evidence of organic synthesis has been obtained.
3. Concentration of [131-I]
iodide is inhibited by the
addition of perchlorate, thiocyanate, iodide and nitrate to the
medium, the order of activity being perchlorate > thiocyanate = iodide
> nitrate, as in vivo.
4. The amount of endogenous
thiocyanate in the gland and plasma is high compared with the amount
which has to be added to the medium to inhibit the concentration of
[131-I] iodide.
5. The addition of 2:4-dinitrophenol
to the medium depresses both the respiration of the slices and their
concentration of [131-I] iodide, indicating that energy is probably
necessary for the process of concentration. 6. Evidence is adduced for a possible competitive-adsorption process to explain the mechanism of concentration.
Antagonism between perchlorate, iodide, thiocyanate, and nitrate for secretion in human saliva; analogy with the iodide trap of the thyroid.Edwards DA, Fletcher K, Rowlands EN Lancet. 1954 Mar 6;266(6810):498-9. [citation only]
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