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Brown-Grant
The effects of castration on the ultrastructure and the iodide-concentrating ability of mouse submaxillary salivary glands.Rogers AW, Brown-Grant K J Anat. 1971 May;109(Pt 1):51-62.
"Previous studies have shown that the submaxillary gland of castrated male mice concentrate inorganic iodide to higher level than those of control males. Glands from both groups of mice have been autoradiographed following an injection of [125-I]-iodide, using a technique that permits the localization of diffusible material. In both groups, iodide was concentrated in the cytoplasm of cells of the convoluted granular tubules (CGT). Lower levels of concentration were also seen in the epithelium of the interlobular ducts and in their luminal contents.
"Cells of the CGT of normal males contained abundant rough endoplasmic reticulum (RER) with many dilated cisternae, and apical secretion granules. Infoldings of the basal cell membrane, with many associated mitochondria, were seen. Following castration, cells of the CGT were smaller: the RER largely disappeared. The infoldings of the basal cell membrane, with their associated mitochondria, formed a conspicuous array visible as basal striations under the light microscope.
"These findings are consistent with the hypothesis that active transport of iodide is a function of the cell membrane, which produces a high concentration of this ion in the cytoplasm. Castration eliminates from the cells the cisternae of RER, reducing the volume of the CGT and of the whole gland, without reducing the volume of the cytoplasmic compartment within which the iodide ion is concentrated."
Failure to demonstrate a concentration of iodide by the submandibular gland of the rat.Brown-Grant K J Physiol. 1963 Mar;165:519-27.
"1. The submandibular gland of the rat does not concentrate iodide in vivo or in vitro. 2. Alterations in gland structure induced by hypothyroidism, castration or large doses of iso-propylnoradrenaline do not result in iodide concentration. 3. Organic binding of iodine by gland slices incubated in a simple saline medium has been demonstrated."
The relation between structure and the concentration of iodide by the submandibular glands of mice and hamsters.Brown-Grant K, Taylor W J Physiol. 1963 Mar;165:508-18.
"1. The gland/blood ratio in vivo and the tissue/medium ratio in vitro for 1311-iodide is higher for the submandibular glands of male than those of female mice. 2. Glands from hypothyroid or castrate male mice show higher ratios than those from normal controls, although the convoluted granular tubules are histologically atrophic. 3. The glands of young mice and hamsters concentrate iodide in vivo before the convoluted granular tubules develop. 4. It is suggested that these ratios measure the iodide-concentrating capacity of the glands and that this capacity is retained or even enhanced in the histologically atrophic tubule."
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