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Iodine and the Body

 

Kidney

Shimoda

 

Preferential renal excretion of iodide derived from thyroxine and triiodothyronine deiodination in man.

Shimoda SI, Kasai K, Kikuchi T, Ieiri T.

J Clin Endocrinol Metab. 1977 Jan;44(1):137-41.

[abstract only]

 

"Tracer doses of 131I- (Carrier free), 131I-T3 and 131-T4 were administered po to 19 healthy male volunteers at intervals 2 to 8 weeks to study whether or not part of the iodide generated in the kidney from T3 and T4 deiodination may enter the renal tubular lumen and be excreted in the urine without entering the blood stream. U(urine)/T(thyroid) ratios of the radioactivity from these materials were employed as the index of the comparison. U/T ratios were severalfold higher 24 h after 131I-T3 or 131I-T4 administration than after 131I-. The data indicate that the 131I- derived from T3 and T4 metabolism is more readily excreted into urine than 131I- which reaches the kidney as inorganic iodide."

 

 

Iodine metabolism: preferential renal excretion of iodide derived from triiodothyronine deiodination.

Shimoda S, Greer MA.

Science. 1972 Mar 17;175(27):1266-7.

[abstract only]

 

"Measurements were made in rats of the relative rates of accumulation in urine or in the thyroid of radioactive iodide derived from simultaneous injections of 131I-labeled triiodothyronine and 125I-labeled iodide. The data indicate that deiodination of triiodothyronine by the kidney results in a loss into the urine of iodine which does not enter the general body iodide pool. This renal "iodide leak" should be considered in kinetic models of iodine metabolism."

 
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