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McCarthy

Effect of diuretics on renal iodide excretion by humans.

Fregly MJ, McCarthy JS.

Toxicol Appl Pharmacol. 1973 Jun;25(2):289-98.

[citation only]

Effect of diuretics on renal iodide excretion by rats and dogs.

McCarthy JS, Fregly MJ, Nechay BR.

J Pharmacol Exp Ther. 1967 Nov;158(2):294-303.

[abstract only]

"Diuretic studies were performed on rats and dogs after acute administration of hydrochlorothiazide, aminophylline, ethacrynic acid, methazolamide and benzolamide. All chioruretic agents studied increased the rate of urinary excretion of iodide. A significant correlation was noted between the logarithms of the rates of chloride and iodide excretion by rats and dogs both prior to and during drug administration. Apparently, drug administration does not alter tubular discrimination between these two anions. The carbonic anhydrase inhibitors, methazolamide and benzolamide, increased bicarbonate, but not chloride, excretion rate and had no significant effect on urinary iodide excretion rate. The increased iodide loss accompanying administration of hydrochlorothiazide and chlorothiazide to rats may explain the goitrogenic effect of these drugs reported earlier."

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