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The Iodine Group | |
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Iodine and the Kidney
Given the importance of the kidney, it is surprising how little research looks at iodine and the kidney.
The NIS (Sodium-Iodide Symporter) has been found in the kidney -- primarily in the distal tubular system, with less in the proximal tubules and none in the glomeruli. The Pendrin transporter and the AIT transporter have also been found in the kidneys.
Renal iodide transport appears to be, at least in part, an active process driven by the NIS.
Iodide clearance in the kidney varies with thyroid status, being lower in hypothyroidism and increased in hyperthyroidism, which is mainly explained by changes of glomerular filtration.
Spitzweg, et al, have investigated the expression of the sodium iodide symporter in human kidney.
Kim, Porra, Suzuki, and Wall discuss the Pendrin, an iodide/chloride transporter found in the inner ear, kidney, and thyroid.
Lacroix et al investigate both the NIS and the Pendrin in the kidney and other tissues.
Gopal and Ganapathy investigated the role of the AIT in the kidney.
Vadstrup has researched renal iodide excretion and the comparative aspects of iodine conservation in mammals.
Matsushima researched iodide transport in the rabbit cortical collecting duct.
Escobar, et al, investigated the effects on thyroid hormones in different body tissues (including the kidney) of various levels of iodine.
Katz has studied thyroid hormones and the kidney.
Vargas et al focus on the effects of thyroid hormones in vascular and renal systems, especially the mechanisms by which thyroid hormones affect the regulation of body fluids.
Pavelka, Babicky, Vobecky look at the competition for excretion of bromide and iodide.
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