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Escobar

Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man.

Pedraza PE, Obregon MJ, Escobar-Morreale HF, del Rey FE, de Escobar GM.

Endocrinology. 2006 May;147(5):2098-108. Epub 2006 Feb 2.

Escobar, et al, investigated the effects on thyroid hormones in different body tissues (including the kidney) of various levels of iodine.

"Figure 5 summarizes the changes observed in T4 and T3 in cerebellum, pituitary, kidney, ovary, adrenal, heart, and muscle with decreasing I availability. T4 decreased in all these tissues following patterns similar to those of plasma T4 or FT4."

"As already described above for the lung, the muscle and heart maintained normal T3 concentrations, even in LID
animals. In these animals, T3 decreased only in the cerebellum, pituitary, and kidney and did so only to 67–73% of C values, less than the decrease in circulating T3."

"The increase in T3 concentration in many of the tissues studied here, such as the liver, lung, kidney, and muscle, were predictable from their known major dependency on plasma-derived T3."

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