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Iodine and the Body

Iodine and the Immune System

• Daniel
• Klebanoff
• Lehrer
• Miller
• Murata
• Sbarra
• Simchowitz
• Simmons
• Spitzweg
• Stolc
• Stone
• Stossel
• Venturi
• Woeber, DeRubertis

MURATA

Hydroxyl radical as the reactive species in the inactivation of phages by ascorbic acid

Murata A, Suenaga H, Hideshima S, Tanaka Y, Kato F

Agricultural and biological chemistry, 1986, vol. 50, no. 6, pp. 1481-1487[citation only]

"Some evidence for the antioxidant effects of iodine or iodide (I-) from studies in vitro....revealed that iodide, thiocyanate and formate are scavengers of OH*, preventing the inactivation of phages by ascorbic acid at concentrations in the mM range." [reference to this article by Winkler, 2000] 

Free radical formation from organic hydroperoxides in isolated human polymorphonuclear neutrophils.

Chamulitrat W, Cohen MS, Mason RP.

Free Radic Biol Med. 1991;11(5):439-45.

[abstract only]

"We have demonstrated with electron paramagnetic resonance (EPR) that organic hydroperoxides are decomposed to free radicals by both human polymorphonuclear leukocytes (PMNs) and purified myeloperoxidase. When tert-butyl hydroperoxide was incubated with either PMNs or purified myeloperoxidase, peroxyl, alkoxyl, and alkyl radicals were trapped by the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO). In the case of ethyl hydroperoxide, DMPO radical adducts of peroxyl and alkyl (identified as alpha-hydroxyethyl when trapped by tert-nitrosobutane) radicals were detected. Radical adduct formation was inhibited when azide was added to the incubation mixture. Myeloperoxidase-deficient PMNs produced DMPO radical adduct intensities at only about 20-30% of that of normal PMNs. Our studies suggest that myeloperoxidase in PMNs is primarily responsible for the decomposition of organic hydroperoxides to free radicals. The finding of the free radical formation derived from organic hydroperoxides by PMNs may be related to the cytotoxicity of this class of compounds."

"There is some evidence for the antioxidant effects of iodine or iodide (I-) from studies in vitro....1 mM potassium iodide has been shown to inhibit DMPO* radical adduct formation by both human polymorphonuclear leukocytes and purified myeloperoxidase." [reference to this article by Winkler, 2000]

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