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Logothetopoulos

Concentration of radio-iodide and 35S-labelled thiocyanate by the stomach of the hamster.

Logothetopoulos JH, Myant NB

J Physiol. 1956 Jul 27;133(1):213-9.

“Iodide is known to be concentrated in gastric juice (Elmer, 1938). In an attempt to identify the cells responsible for concentrating iodide in human gastric juice, Honour, Myant & Rowlands (1952) measured the gastric juice/ plasma radio-iodide concentration ratio (GJ/P ratio) in patients given injections of radio-iodide in conditions in which the secretion of acid and pepsin varied. Their results suggested that the iodide-concentrating mechanism does not depend on the acid- or pepsin-secreting cells, but their evidence was not conclusive. Thiocyanate is also known to be concentrated in gastric juice (Crandall & Anderson, 1934), and to inhibit the concentration of iodide by the stomach (Mason, Kirschbaum & Collins, 1951). It seemed of interest, therefore, to see whether iodide and thiocyanate are concentrated by the same cells of the stomach. Most of our observations were made on hamsters, but a few results obtained with mice, rats and guinea-pigs are also included in this paper.”

“1. Radio-iodide and 35S-thiocyanate are concentrated in the gastric juice and glandular stomach wall of hamsters, mice, rats and guinea-pigs. The 1311 gastric juice/plasma concentration ratio (GJ/P) varied from 6-0 to 26-2; the ratio for 35S varied from 5-6 to 33-8.

2: After injections of radio-iodide or 35S-thiocyanate into pregnant guinea-pigs, the GJ/P ratios in the foetus were not significantly different from those observed in adult guinea-pigs.

3. Autoradiographs made from freeze-dried sections showed that selective concentration of iodide and thiocyanate occurs in the cells of the surface epithelium and gastric pits of the fundus and pyloric part of the stomach. Selective concentration was not observed in the fore-stomach, gastric glands, duodenum, jejunum, ileum or colon.

4. After injections of radio-iodide or 35S-thiocyanate, most of the radioactivity concentrated in the gastric juice and stomach wall was identified as unbound iodide or unbound thiocyanate.”

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