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Brown-Grant

The secretion of radioactive iodide by the stomach of the anaesthetized dog in relation to total gastric blood flow and to acid secretion.

Brown-Grant K, Summing JS, Haigh AL, Harries EH

J Physiol. 1965 Apr;177:337-45.

"1. The gastric clearance of radioactive iodide, acid secretion and total gastric blood flow have been measured in anaesthetized dogs.
2.  Low doses of histamine increased the rate of acid secretion and iodide clearance comparably but at higher doses acid secretion was increased to a greater extent than iodide secretion.

3.  The effects of adrenaline and noradrenaline infusions on histamine-induced acid and iodide secretion were in general the same but the extent to which the two processes were affected was not usually the same.

4.  5-Hydroxytryptamine stimulated iodide secretion by the stomach, producing a small volume of secretion of very high iodide concentration relative to the blood; no effect on acid secretion was observed.  No consistent effects of 5-hydroxytryptamine on histamine-induced acid or iodide secretion were observed.

5.  These findings support the view that iodide and acid secretion are separate and distinct processes.

6.  During vigorous histamine-induced secretion the fraction of the total gastric blood flow passing through the mucosal capillaries must be at least 0.3-0.4.

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