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Debski
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.Debski MG, Pachucki J, Ambroziak M, Olszewski W, Bar-Andziak E. Thyroid. 2007 Jan;17(1):3-10. [abstract only]
"Type 1 5'-deiodinase
is one of two isoenzymes that participate in conversion of
prohormone thyroxine into triiodothyronine (T3). A decrease in
type 1 5'-deiodinase expression was observed in renal clear cell
carcinoma, thyroid cancer, and lung cancer. The aim of this study
was to evaluate type 1 5'-deiodinase activity and mRNA level in
breast cancer tissue and non-cancerous surrounding breast tissue.
Material was collected from 36 patients undergoing radical
mastectomy or local tumor resection. In all non-cancerous breast
tissues, type 1 50-deiodinase activity was found to be at a very
low or immeasurable level, and type 1 5'-deiodinase mRNA was
detected only in 2 out of the 36 samples. By contrast, 20 out of
the 36 breast cancer tissues, mainly grades G1 and G2, expressed
abundant type 1 5'-deiodinase activity and/or a high mRNA level.
Our data demonstrated the presence of type 1 5'-deiodinase in
well-differentiated breast cancer tissue. High enzymatic activity
of type 1 50-deiodinase can potentially lead to an increase in
the production of T3, which may affect target gene transcription,
including genes responsible for energy expenditure, growth,
differentiation, and proliferation." |
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