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Iodine and the Breast  

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Brown-Grant

Iodinated compounds in milk after radio-iodide administration.

Brown-Grant K, Galton VA

Biochim Biophys Acta. 1958 Feb;27(2):422-3.

[citation only]

The iodide concentrating mechanism of the mammary gland.

Brown-Grant K

J Physiol. 1957 Mar 11;135(3):644-54.

"1. The milk/plasma ratio for 131I has been studied for periods up to 6 hr after injection in anaesthetized rabbits and values between 6.7 and 37.4 were found. Methylthiouracil had no effect on the establishment of a high M/P ratio.

2. The M/P ratio was depressed by various anions, the order of potency being: ClO4- > SCN- >/= I- > IO3 > NO3 > BrO3-. Bromide and chloride had no effect.

3. A concentration gradient for 131I between milk and plasma was also found in guinea-pigs, rats and mice and was shown to be reduced by thiocyanate.

4. No evidence was obtained for the concentration of thiocyanate in the milk during inhibition of iodide concentration by this anion.

5. A small proportion (up to 5%) of the radio-iodine found in rabbit's milk appears to be in organic combination. This fraction is not seen after methylthiouracil administration.

6. The iodide metabolism of the mammary gland is discussed and compared with that of the thyroid and other extra-thyroidal iodide concentrating tissues."

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