Arturi. Iodine and the Breast -- Research

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Iodine and the Body Iodine and the Breast Aceves Arturi, Filetti Bezpalov Brown-Grant Cann Carrasco Cho Clur Debski Derry Douglass Eskin-Ghent Flechas Funahashi Garcia-Solis Giani Hartmann Howenstine Iwamoto Kapdi Kessler Kogai Lim, Moon Natarajan Park Perron Rillema Saraiva Sekiya Shrivastava Skibola Smyth Spitzweg Strum Tazebay Teas Torremante Turken Upadhyay Venturi Wapnir West	ARTURI, Filetti Regulation of iodide uptake and sodium/iodide symporter expression in the MCF-7 human breast cancer cell line. Arturi F, Ferretti E, Presta I, Mattei T, Scipioni A, Scarpelli D, Bruno R, Lacroix L, Tosi E, Gulino A, Russo D, Filetti S. J Clin Endocrinol Metab. 2005 Apr;90(4):2321-6. Epub 2004 Dec 28. "Sodium/iodide symporter (NIS) expression has recently been described in human breast cancer, with emphasis on its potential exploitation for the treatment of these tumors with radioiodine. In this study, we analyzed the regulation of NIS expression and function in the MCF-7 human breast cancer cell line. Cell exposure to insulin, IGF-I, IGF-II, or prolactin induced significant increases in 125I uptake and the expression of both NIS mRNA and NIS protein. The latter increases were evident after 6 and 12 h of hormonal stimulation, respectively. In immunocytochemistry studies, NIS was detected mainly in the plasma membrane of MCF-7 cells. A low but significant increase in iodide uptake was produced by treatment with activators of the adenylyl cyclase (cAMP) or protein kinase C pathways. Our study demonstrates that: 1) MCF-7 breast cancer cells are capable of active iodide transport that can be stimulated by insulin, IGF-I, IGF-II, or prolactin; 2) both NIS transcript and protein are expressed in these cells, and this expression is also hormonally stimulated; and 3) MCF-7 iodide transport and NIS expression may be influenced by the activation of cAMP or protein kinase C-dependent signaling. These findings increase our understanding of the molecular mechanisms that regulate NIS expression in breast cancer cells, information that is fundamental for future research aimed at the development of targeted radioiodide treatment for this type of cancer." More articles by Filetti
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