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ADAMS
Sulfhydryl-reactive metals in autism.Kern JK, Grannemann BD, Trivedi MH, Adams JB. J Toxicol Environ Health A. 2007 Apr 15;70(8):715-21. [abstract only]
"This study examined the difference between sulfhydryl-reactive metals (mercury, lead, arsenic, and cadmium) in the hair of 45 children with autism (1-6 yr of age) as compared to 45 gender-, age-, and race-matched typical children. Hair samples were measured with inductively coupled mass spectrometry. Some studies, such as Holmes et al. (2003), suggested that children with autism may be poor detoxifiers relative to normally developing children. Metals that are not eliminated sequester in the brain. Our study found that arsenic, cadmium, and lead were significantly lower in the hair of children with autism than in matched controls. Mercury was in the same direction (lower in autism) following the same pattern, but did not achieve statistical significance. The evidence from our study supports the notion that children with autism may have trouble excreting these metals, resulting in a higher body burden that may contribute to symptoms of autism."
Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers.Adams JB, Holloway CE, George F, Quig D. Biol Trace Elem Res. 2006 Jun;110(3):193-209. [abstract only]
"The objective of this study was to assess the levels of 39 toxic metals and essential minerals in hair samples of children with autism spectrum disorders and their mothers compared to controls. Inductively coupled plasma-mass spectrometry was used to analyze the elemental content of the hair of children with autism spectrum disorders (n=51), a subset of their mothers (n=29), neurotypical children (n=40), and a subset of their mothers (n=25). All participants were recruited from Arizona. Iodine levels were 45% lower in the children with autism (p=0.005). Autistic children with pica had a 38% lower level of chromium (p=0.002). Autistic children with low muscle tone had very low levels of potassium (-66%, p=0.01) and high zinc (31%, p=0.01). The mothers of young children with autism had especially low levels of lithium (56% lower, p=0.005), and the young children (ages 3-6 yr) with autism also had low lithium (-30%, p=0.04). Low iodine levels are consistent with previous reports of abnormal thyroid function, which likely affected development of speech and cognitive skills. Low lithium in the mothers likely caused low levels of lithium in the young children, which could have affected their neurological and immunological development. Further investigations of iodine, lithium, and other elements are warranted."
Toxic Metals and Essential Minerals in the Hair of Children with Autism and their MothersAdams JB, Holloway CE, George F, Quig D
"Iodine levels were 45% lower in the children with autism (p=0.005). "
Hair Analysis of Children with Autism and their MothersAdams JB, Holloway CE, George F, Quig D
"Iodine: Children with autism have low levels of iodine (needed for proper thyroid functioning and to prevent mental retardation). Iodine deficiency is the most common worldwide cause of mental retardation."
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