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ESCOBAR
Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man.Pedraza PE, Obregon MJ, Escobar-Morreale HF, del Rey FE, de Escobar GM. Endocrinology. 2006 May;147(5):2098-108. Epub 2006 Feb 2.
"As already described for the liver, lung, brain, and BAT, the patterns of change in T3 varied greatly among these other tissues. The greatest difference was found between the patterns for the ovary and adrenal. In the ovary there is a very remarkable increase of T3... On the contrary, T3 in the adrenal decreases steadily with decreasing I availability, almost in parallel to adrenal T4, and more markedly than circulating T3; values in the adrenals of LID' [Low Iodine Diet + perchlorate] animals are only 17% of those of the C [Control -- adequate iodine] group, whereas plasma T3 is still 46%. As already described above for the lung, the muscle and heart maintained normal T3 concentrations, even in LID' animals. In these animals, T3 decreased only in the cerebellum, pituitary, and kidney and did so only to 67-73% of C values, less than the decrease in circulating T3."
"The lack of increase of T3 content of the adrenals had also not been anticipated because this tissue has been considered dependent on serum-derived T3."
"In summary, both intra-and extrathyroidal mechanisms are involved in the response of the rat to mild ID: the former are autoregulatory and very effective in avoiding T3 deficiency in most tissues, and the latter occur in tissues in which D2 is important for local generation of T3. In mild ID, hypothyroidism, as inferred from the concentrations of T3, is avoided in all tissues studied."
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